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Supports Glucose Metabolism and Antioxidant Status
120 Tablets

Glucose Optimizer
by Jarrow
Supports Glucose Metabolism and Antioxidant Status
Price
Quantity
Suggested Size of Dose
1 Tablet
Total Number of Doses
Price per Dose
$ 19.16
120 Tablets
2300mg
120
.15
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Dosage / Usage
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For the 120 Tablets / 2300mg - Take up to 4 tablets per day with meals

Please consult with a qualified professional before taking any Vitamins, Extracts, or Herbal Supplementations.


Description
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Glucose Optimizer™ is a comprehensive combination of nutrients that improve glucose metabolism and antioxidant protection.

Alpha Lipoic Acid facilitates reduction of blood glucose and supports general metabolism by its effects on energy production.

GlucoTrim is an extract of Crepe myrtle, which contains corosolic acid, an activator of glucose transport. Other herbal extracts that have glucose regulating properties include Gymnema, Bitter Melon, Fenugreek and Eucalyptus.

Green Tea Extract (45% Polyphenols) supports the strength of capillaries and other blood vessels.

Magnesium is involved in the metabolism of glucose and production of energy in the form of ATP.

Bilberry promotes healthy eye function and circulation.

A Comprehensive and Synergistic Combination

of Nutrients and Herbal Extracts to Nutritionally

Support Blood Sugar Balance

Dietary Sources of Blood Sugar Imbalances

In 1975, T.L. Cleave, M.D., published The Saccharine Disease, which argues that blood sugar control problems are characteristic of modern Western diets. Twenty years later, Americans ages 2 years and older consumed the equivalent of 82 grams (2.9 ounces) of sugars per day from added sweeteners, which accounted for 16% of all calories consumed. This figure, which comes to more than 65 pounds per person per year(!), does not include the sugars added to foods as binders, fillers, preservatives, and so forth, nor the sugars that occur naturally in fruits, milk, etc. In recent years, in part as a result of the campaign to reduce the amount of fat in the American diet, the consumption of simple sugars has rocketed even further upward, with per capita consumption now reaching between 149 and 152 pounds per year!

Blood Lipids - Blood Sugar - Antioxidant Balance

High levels of blood fats and blood sugar interfere with each other's proper regulation and metabolism. On the one hand, the presence of excess glucose in the blood interferes with the use of fat for energy and, through the action of the liver, elevates the level of triglycerides and their storage as fat. On the other hand, the presence of excess fats in the blood interferes with the disposal of glucose.

To optimize the regulation of blood sugar, both bloodglucose levels and blood fat levels must be taken into account. This is why Glucose Optimizer provides a unique combination of ingredients designed to address both of these issues while simultaneously protecting the body against the oxidative stress associated with elevated levels of blood glucose and insulin.

Chromium

Chromium is the mineral most associated with blood sugar control because in its trivalent form it appears to improve the absorption of glucose into the cells. Chromium potentiates the effects of insulin by improving its ability to bind to its cellular receptor. If a lack of chromium is responsible for the suboptimal clearance of blood sugar by insulin, supplemental chromium will mean that less insulin is needed to control blood sugar levels. Energy levels therefore can be stabilized and the extreme fluctuations of hunger associated with hypoglycemia can be avoided because there is no longer an excessive release of insulin. The usefulness to the dieter and to those with tendencies to high blood sugar is obvious. Just as important, however, is the fact that chromium has been shown to help moderately decrease unwanted blood lipid levels, both of LDL cholesterol and of triglycerides, while actually raising the levels of the desirable HDL fraction of the blood.

Glucose Optimizer Advantages

Contemporary research has identified compounds that have much stronger effects directly upon glucose transport than trivalent chromium, such as alpha-Lipoic Acid and Colosolic Acid. Niacinamide is another nutrient which significantly modulates glucose metabolism, in part by improving both insulin response and insulin release. All four of these nutrients are found in Glucose Optimizer and are broadened by the inclusion of herbal extracts that improve pancreatic beta-cell functioning.

Alpha Lipoic Acid: The Antioxidant Glucose Regulator

Known primarily as an antioxidant that protects both water-based and fat-based tissues, alpha-lipoic acid is also a potent regulator of blood sugar. It has a direct effect upon one or more of the cellular glucose transporters, proteins found inside cells which transport glucose across the cell membrane. Alpha-lipoic acid inhibits the inappropriate release of glucose by the liver, such as when the liver releases yet more glucose into the blood even as the pancreas is releasing insulin to help clear the glucose already present. Of all the nutritional glucose modulators available, alpha-lipoic acid is the most powerful, most versatile, and most extensively tested.

Colosolic Acid

Derived from the herb Lagerstroemia speciosa L., otherwise known as crepe myrtle or the banaba tree, colosolic acid is a relatively new glucose disposal agent. Colosolic acid has been shown to regulate blood glucose levels in humans. From in vitro (test tube) studies, colosolic acid appears to work by stimulating the cell's glucose transporters.

Another interesting finding is that colosolic acid may be useful in weight loss. This is not true of many compounds which help to regulate blood sugar levels. Colosolic acid is a versatile blood sugar modulating agent.

Gymnema Sylvestre

The herb Gymnema sylvestre has been used in Indian Ayurvedic medicine for 2000 years to positively modulate carbohydrate metabolism. Animal studies have confirmed that the herb does indeed reduce blood sugar levels. Other studies demonstrate that gymnema extracts increase liver and pancreas functions, which tend to be weakened in those who are overweight or experience blood sugar regulatory problems. Another significant factor to dieters is the fact that gymnema is claimed traditionally to reduce cravings for sweet foods; it does this by mildly affecting the taste receptors. Western-style researchers have determined that Gymnema sylvestre may work by repairing or regenerating the actual insulin-producing cells of the pancreas and thereby increase insulin output.

Glucose Optimizer

Vitamin C - antioxidant; may improve insulin's actions; partially dependent upon insulin for entry into the cell

Niacinamide - enhances insulin sensitivity and secretion

Vitamin B-1 - essential for carbohydrate metabolism, energy production and nerve cell function

Vitamin B-5 - supports the utilization of carbohydrates and fats in energy production

Vitamin B-6 - supports nerve health; inhibits the crosslinking of proteins by sugars

Vitamin B-12 - supports nerve health; important for energy production; methyl donor

Biotin - enhances insulin sensitivity and glucokinase activity in the liver

Folic Acid - methyl donor that works with B-6 and B-12 to lower homocysteine levels

Vitamin E - antioxidant; enhances insulin sensitivity

Magnesium - may enhance the secretion and actions of insulin; important for the desaturation of fats and for production of energy in the form of ATP

Manganese - important for blood sugar control, energy production and thyroid function; supports the production of the antioxidant superoxide dismutase (SOD)

Selenium - antioxidant; works with vitamin E; supports immune health

Chromium - part of 'glucose tolerance factor;' works with insulin at its receptor site on the cell to improve the cellular absorption of glucose (regulate blood sugar metabolism)

Alpha-Lipoic Acid - antioxidant; enhances insulin sensitivity; mimics insulin's actions; improves glucose transport into the cells; rehabilitates and spares vitamins C and E; rehabilitates CoQ-10; reduces glycation

GlucoTrim (colosolic acid) - enhances the actions of the cellular glucose transporters for improved blood sugar regulation

Gymnema Sylvestra - increases ability of beta-cells to produce insulin; may reduce taste for sugars (75% gymnemic acids)

Bilberry Extract - supports the production of visual purple in the eye; antioxidant that protects the health of the eyes and capillaries (24% anthocyanosides)

Green Tea Extract - supports the health of the capillaries and other blood vessels (45% polyphenols)

Bitter Melon - mimics some of the actions of insulin to reduce blood sugar levels

Fenugreek Fiber Extract - blood sugar lowering properties

Eucalyptus Leaf Extract - supplies antioxidant bioflavonoids

Taurine - acts as a minor insulin mimic; antioxidant; stabilizes cell membranes

Supplemental Facts

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Serving Size 4 Tablets Amount % DV

Vitamin C (Ascorbic Acid) 300 mg 500%
Niacinamide 300 mg 1500%
B1 (Thiamine Mononitrate) 5 mg 333%
B5 (Pantothenic Acid) 25 mg 250%
B6 (Pyridoxine HCl) 5 mg 250%
B12 (Methylcobalamin) 100 mcg 1667%
Biotin (Thiamine Mononitrate) 1,000 mcg 333%
Vitamin E (as tocopheryl succinate) 100 IU 333%
Folic Acid (Folate) 400 mcg 100%
Magnesium (as Oxide) 200 mg 50%
Manganese (from citrate) 1 mg 50%
Selenium (as Methylselenocysteine) 50 mcg 71%
Chromium (from 100mg Saccharomyces cerevisiae nutritional yeast) 200 mcg 100%
Alpha Lipoic Acid 200 mg *
GlucoTrim (Crepe myrtle Extract) 48 mg *
Gymnema Sylvestre (75% Gymnemic acids) 300 mg *
Bilberry (Vaccinium myrtillus) (25% Anthocyanosides) 40 mg *
Green Tea 5:1 Extract (Camellia sinensis) (45% Polyphenols) 200 mg *
Bitter Melon (Momordica charantia) 200 mg *
Fenugreek Fiber Extract (Trigonella graecum) 150 mg *
Eucalyptus Leaf Extract (Eucalyptus globulus) 100 mg *
Taurine 300 mg *
* % Daily Value not established.

References Back to Top

1. Guthrie JF, Morton JF. Food sources of added sweeteners in the diets of Americans. J Am Diet Assoc 2000 Jan; 100(1 ):43-51, quiz 49-50

2. Gittleman AL. Get the Sugar Out. (New York: Crown Trade Paperbacks, 1996); Steward HL, et al. Sugar Busters (1995); U.S. Department of Agriculture figures.

3. Brand JC, Nicholson PL, Thorburn AW, Truswell AS. Food processing and the glycemic index. Am J Clin Nutr. 1985 Dec;42(6): 1192-6.

4. Lipetz P. The Good Calorie Diet. (New York: HarperCollins Publishers, 1994) 28.

5. Felber J-P, Acheson KJ, Tappy L. From Obesity to Diabetes. (New York: John Wiley & Sons, 1993), Chapter 4, 'Insulin Resistance.'

6. Gatti E, Noe D, Pazzucconi F, Gianfranceschi G, Porrini M, Testolin G, Sirtori CR. Differential effect of unsaturated oils and butter on blood glucose and insulin response to carbohydrate in normal volunteers. EurJ Clin Nutr. 1992 Mar;46(3):161-6.

7. Preuss HG, Anderson RA. Chromium update: examining recent literature 1997-1998. Curr Opin Clin Nutr Metab Care. 1998 Nov;1(6):509-12. Review.

8. Packer L, Witt EH, Tritschler HJ. alpha-Upo\c acid as a biological antioxidant. Free Radio Biol Med. 1995 Aug;19(2):227-50. Review.

9. Jacob S, Henriksen EJ, Tritschler HJ, Augustin HJ, Dietze GJ. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabetes. 1996;104(3):284-8.

10. Khamaisi M, Potashnik R, Tirosh A, Demshchak E, Rudich A, Tritschler H, Wessel K, Bashan N. Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats. Metabolism. 1997 Jul;46(7):763-8.

11. Blumenthal SA. Inhibition of gluconeogenesis in rat liver by lipoic acid. Evidence for more than one site of action. Biochem J. 1984 May 1;219(3):773-80.

12. Ikeda Y. The clinical study on the water extract of leaves of Lagerstroemia speciosa L. for mild cases of diabetes mellitus. Jikeikai University and the Japan Diabetes Association 1999.


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